The Cure for the Common CryptoCurrency

CureCoin is a CryptoCurrency based on coupling SHA-256 Mining and [email protected] Protein Folding.

1.0
Learn
Learn about CureCoin, a powerful new way to create a CryptoCurrency.

Read More
 
2.0
Fold
Use your CPUs & GPUs to Fold Proteins for Stanford's [email protected] program, earning CureCoins.
Read More
 
3.0
Mine
Use SHA-256 ASIC hardware to Mine CureCoin and secure the blockchain for everyone.
Read More
 
 

On our two year anniversary, we’d like to highlight some of the actual scientific progress made by the [email protected] community (including the CureCoin team) since our 2014 inception:


Introduction

Although we’d like to take more credit, it’s humbling to be part of a global movement of teams and individuals so committed to Protein Folding research. A lot of work remains on our part to catapult the CureCoin Team to the #1 ranking - although we have managed to reach the #4 spot in under two years - beating out several large corporate-sponsored teams along the way. We envision a combination of corporate and cryptocurrency mining community interest in CureCoin are the keys to accelerating research going forward.

“We’re pushing to design drugs that are (disease) selective at higher doses, without side effects that almost kill patients” - Vijay Pande (Paraphr. CoinDesk 2013 article)

“...techniques that we develop here very naturally have been applied to cloud computing, further broadening the impact of FAH’s scientific impact.” [email protected] blog 2016 projections



...So how does "Protein Folding" help?

Drug design has traditionally been slow, costing 100’s of millions of dollars, and is prone to stalling in Phase II trials. In projects like [email protected], the rewards are long-term. In-silico research is done at the earliest stages of the FDA drug approval process (see figure below). In addition to the study of multiple diseases (both infectious, and proteopathy in which proteins become structurally abnormal), [email protected] focus is on researching protein folding dynamics. Since proteins spend up to 96% of folding time "waiting" in various “intermediate conformational states”, there are countless, as yet undiscovered molecular interactions - especially those related to drug design.

... So the answer to the original question is - "it's complicated" - but read on for a great example:

Historical perspective using a series of Alzheimer's Disease Studies


Protein folding creates more opportunities in the early phases of drug design as well as enzyme research. As more computational power is added by contributors, the more "super complex systems" (like ion channels) can be explored in ways not possible a decade ago.

Clinical Trials
FDA Clinical Trials Phases


Acknowledgement of the [email protected] community in Pande Lab Scientific Papers since 2014

Conformational heterogeneity of the calmodulin binding interface
Free energy landscape of activation in a signalling protein at atomic resolution
Activation pathway of Src kinase reveals intermediate states as targets for drug design.
A network of molecular switches controls the activation of the two-component response regulator NtrC
Cloud computing approaches for prediction of ligand binding poses and pathways(credit Google)

Publicly available Papers [email protected] since 2014 (reverse order)

129. MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories.
128. Heat dissipation guides activation in signaling proteins.
127. Efficient maximum likelihood parameterization of continuous-time Markov processes
126. United polarizable multipole water model for molecular mechanics simulation.
125. OpenMM: A Hardware Independent Framework for Molecular Simulations.
124. A network of molecular switches controls the activation of the two-component response regulator NtrC.
123. Elucidating Ligand-Modulated Conformational Landscape of GPCRs Using Cloud-Computing Approaches.
122. Variational cross-validation of slow dynamical modes in molecular kinetics.
121. Revised Parameters for the AMOEBA Polarizable Atomic Multipole Water Model.
120. Markov state models provide insights into dynamic modulation of protein function.
119. Cloud computing approaches for prediction of ligand binding poses and pathways.
118. Activation pathway of Src kinase reveals intermediate states as targets for drug design.
117. Statistical model selection for Markov models of biomolecular dynamics.
116. Dynamical Phase Transitions Reveal Amyloid-like States on Protein Folding Landscapes.
115. Describing protein folding via temperature-jump two-dimensional infrared spectroscopy and Markov state models.

CureCoin Cryptocurrency Update (SigmaX and CC 2.0):

Earlier this year, CureCoin announced a change in direction for CureCoin 2.0. Rather than having a single coin, the new blockchain will result in two coins. One will be CureCoin 2.0 (purely based on folding), the other will be a traditional PoW model called SigmaX. While both will share the same decentralized blockchain model, and both will be quantum resistant and utilize Merkle Tree Signatures; SigmaX is being developed for those who feel CureCoin’s dependency on signing certificates from DCN research lacks the purity required to compete in a decentralized cryptocurrency market on its own. CureCoin holders will be allowed to participated in SigmaX based on their holdings. You can read all the details and join the sometimes colorful conversation on our bitcointalk thread

Business Recap:

CureCoin is now available to trade on LiveCoin.net (and trading with our long time partners at Bittrex.net and Poloniex exchanges). Additionally CureCoin is listed on the CoinPayments.net marketplace which gives CureCoin the *potential* to reach a trusted network of over 31,000 registered vendors around the world. As part of the latest Fintech infrastructure, CoinPayments gives buyers and sellers peace-of mind through protected, secured transactions. Register your business to accept CURE today at CoinPayments.net!

Donations Status:

A special acknowledgement to our top folder - Ed Olkkola, whose massive donations of CURE (generated purely from his folding activities) are helping, or have helped fund donations to ANTRUK, Bonfils.org, Pande Labs, U-foundation Zambia, and the Rwanda Dream Medical Center. We've chosen to start converting Ed's donations on the markets dynamically, so you wont see a large lump-sum of coins in the donation wallets which could impact the market price if they're sold off too fast.

The Costs of Folding:

What are the actual costs behind producing this much computational research through [email protected]?
(Converting Points per Day PPD to CURE):
Estimate your own costs with our online calculator(beta)
… or see our
Dec 2015 estimates based on 12 Equipment profiles.


The IRC Channel is back!

Please feel free to join us on the CureCoin IRC Channel for anything that's on your mind:
A new secure bot is back online, and tipping is available.

Also, we've found some members use bitcointalk and other social media sites for technical support issues. If at all possible, please use our support forum instead. This helps us track tech support issues in one place, and makes them searchable for everyone with similar questions.

Thanks and Happy Folding,
The CureCoin Team

Download Wallet

Windows (Portable)

Download

Windows (Installer)

Download

Mac OSX

Download

Linux / Source

GitHub Source

Donate CureCoin to the Folding @ Home project and help us support Pande Labs at Stanford.

See what donations will be used for at Stanford's website.

2384.8172 CURE
BAxZtUJfAR7YpsSc1K5R24NhwaAJnc7sab


Donate CureCoin to the CureCoin project.

Our goal with this fund is to get registered as a 501(c)3 Charity, fund our Social-Media promos like giveaways, website, forum and IRC maintenance.

2 CURE
B5es5DcgGS3xYNcfWPjDZimNkpqmRaiUUJ


* 60% Donated CureCoins go to Antibiotic Research UK
World's first charity to fight Antibiotic Resistance.
Learn More on the ANTRUK homepage.
* 40% Donated CureCoins go to Bonfils Blood Center
Part of national Blood Systems, Inc. providing a safe & adequate blood supply along with transfusion research.
Learn More on the Bonfils Blood Center homepage.

502.00 CURE
BD6jNgZ5Rj6zW4WGZAgAY8HQy1cPhE4DYm


Donate CureCoin to ThumbsUp International

Experiencing life's promise by matching abled bodied and adaptive athletes to compete in swim, bike, run and triathlon events.

Learn More on the ThumbsUp International homepage.

256.29668 CURE
B7j3fFRKaZykw7CS9x1b6N1F2cnpZ3AP32

CureCoin on Twitter

CureCoin_Team Stanford University 1-Cent "Lab On A Chip" Could Revolutionize Medical Diagnosis https://t.co/t0ACGI9KUy via @curiositydotcom
CureCoin_Team RT @Poloniex: 1/3 IMPORTANT NOTICE: Due to the widespread impact of Cloudflare's recently-discovered parser bug #cloudbleed
CureCoin_Team @Aurum420 @gambinifra @foldingathome Aurum, following these steps to earn 4 different coins 4 same amount of folding https://t.co/zYpcd6RyPe

Select Site Language (beta)

Site Information

All website content is provided for CureCoin enthusiasts only. [email protected] is not affiliated with CureCoin in any official capacity, and is the property of Pande Labs and Stanford University.

Contact Us

[email protected] (Website)